This paper deals with the performance of Half Duplex (HD) and Full Duplex (FD) in different fading channels via relay networks. A new Heterogeneous Multiplex Relay (HMR) protocol is proposed for the achievement of spectrum efficiency over Multiple Input and Multiple Output (MIMO) using HD and FD. The Key idea of the protocol the relay selection among half duplex and full duplex for overcoming fading which achieves diversity and multiplexing gain. The protocol is projected in Massive MIMO with Opportunistic Relay Selection which requires limited feedback/signaling for relay and operation mode selection. The max-min criteria help in finding the best channel which leads to the best relay selection. Consideration of the Coded Cooperation and Successive Interference Cancellation helps recovery of the loss of Multiplexing Gain. Simulation result shows the throughput performance of Heterogeneous Multiplex Relay (HMR) protocol compared to HD and FD. HMR protocol provides 80% capacity performance due to its allotted channels between HD and FD. It also shows the performance of Bit Error Rate (BER) vs Signal to Noise Ratio (SNR) values compared to Rayleigh, Rician, and Nakagami Fading Channels.

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